# Biostats SPSS Kaplan-Meier Curve

Due 4/20/19 11p.m EST
Be on time and ORIGINAL WORK!
DATA ATTACHED ALONG WITH STEP BY STEP GUIDE!

The Kaplan-Meier curve is a way to evaluate longitudinal data and estimate conditional survival rates through the illustration of a series of conditional probabilities.
For this Assignment, you use the Kaplan-Meier method to evaluate time-to-event data collected through a longitudinal study described in the Week 8 Dataset (SPSS document). You also create a survival curve and estimate survival distributions.

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The Assignment
Using Wk 8 Dataset (SPSS document)

Data

Create a variable for Time-to-event by subtracting the start time (variable = start) from the stop time (variable = stop). Label the new variable “Time”.
Produce the appropriate descriptive statistics, numerical and graphical, for the following variables:

Event
Interval
Tx
Num
Size
Time

Kaplan-Meier Survival Analysis (Without factor or Strata)

Run a Kaplan-Meier analysis in SPSS, using Time as the Time variable and Event as the Status variable (Be sure to define the event). Do not add a factor or strata at this time.
Produce a Survival Table (you do not need to submit this)
Produce a plot of the survival function
What is the mean survival time (include confidence intervals)? What is the median survival time (include confidence intervals)? Why do you think they are so different from each other?

Kaplan-Meier Survival Analysis (With Factor)

Run a Kaplan-Meier analysis in SPSS, using Time as the Time variable and Event as the Status variable (Be sure to define the event). Add Tx as the factor.
Test the difference between Tx groups (Compare Factor) using Log-Rank, Breslow, and Tarone-Ware
Produce a plot of the survival function
Describe what the Overall Comparisons mean in terms of treatment groups and survival times.
Kaplan-Meier Survival Analysis (With Strata)

Run a Kaplan-Meier analysis in SPSS, using Time as the Time variable and Event as the Status variable (Be sure to define the event). Add Interval as the Strata variable.
Produce a plot of the survival function for each strata.
Why would you want to produce Kaplan-Meier Survival Curves after stratifying for a variable?

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